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America’s Vast Infrastructure

President Elect Donald  Trump’s plan to invest about $550 billion in new infrastructure projects across the country was a central theme in his campaign. “We’re going to rebuild our infrastructure, which will become, by the way, second to none. And we will put millions of our people to work as we rebuild it,” Trump said. Details are still murky, but it appears that the plan will rely on tax credits to spur private investment.The maps you are about to see show the massive scope of America’s infrastructure using data from OpenStreetMap and various government sources. They provide a glimpse into where that half-trillion dollars may be invested.

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New Ways Found to Suppress Cancer Immunity

Previous studies have identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, contrary to that researchers from University of California reveal a surprising role for these enzymes in subduing cancer immunity. Published in the journal Cell, the findings could have a clinical role in improving efficiency of immunotherapy drugs. “Before our study, no one knew that the Hippo pathway was regulating immunogenicity,” said first author Toshiro Moroishi. Adding, “LATS1/2 deletion in cancer cells improves tumor immunogenicity, leading to the destruction of cancerous cells by enhancing anti-tumor immune responses.”Published in the journal Cell, the findings could have a clinical role in improving efficiency of immunotherapy drugs. “Before our study, no one knew that the Hippo pathway was regulating immunogenicity,” said first author Toshiro Moroishi. Adding, “LATS1/2 deletion in cancer cells improves tumor immunogenicity, leading to the destruction of cancerous cells by enhancing anti-tumor immune responses.”
Hippo pathway signaling regulates organ size by moderating cell growth, apoptosis and stem cell renewal but dysregulation contributes to cancer development. In vitro studies of Hippo pathway kinases LATS1/2 showed that the loss of these enzymes promoted cell proliferation and tumor survival. In vivo research using immune-compromised mouse models also supports a tumor suppressor function of the Hippo pathway.

However, when Moroishi and team deleted LATS1/2 from mouse cancer cells and examined tumor growth in models with healthy immune systems researchers found that immunogenicity — the ability to stimulate an immune response — improved, destroying cancer cells. Researchers caution that immune systems of mouse models are different from the human immune system so the response might be different and further studies are needed.

If the outcome proves to be the same, using a LATS1/2 inhibitor alone or in combination with an immune checkpoint inhibitor may stimulate the immune system of patients that previously did not respond to immunotherapy treatments. Currently, most immunotherapy research focuses on targeting the immune system, but the new findings reveal that tumor cells may also be vulnerable to inhibitors.

“Inhibiting LATS1/2 could be an attractive approach to treat cancer,” said Kun-Liang Guan. Adding, “LATS is an ideal target because there are many kinase inhibitors that have been successfully developed as cancer drugs.”

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Doctors Say NUTS Should Be Prescribed To Help Beat Killer Diseases

Just a 1oz portion is enough to slash the risk of heart disease, cancer and even obesity. Analysis suggests even a small daily serving cuts the risk of coronary heart disease by 30 per cent, cancer by 15 per cent and premature death by 22 per cent. It can also halve the risk of respiratory disease and reduces diabetes by nearly 40 per cent. Nuts are thought to possess such health-boosting properties some experts think they should be widely prescribed on the NHS. Study co-author Finnegan Aune, of the School of Public Health at Imperial College, London, said: “We found a consistent reduction in risk across many different diseases, which is a strong indication there is a real underlying relationship between nut consumption and different health outcomes. “It’s quite a substantial effect for such a small amount of food.Nuts are considered a super food because they posses anti-inflammatory qualities and are also high in protein and fiber. Researchers analysed 29 global studies involving 819,000 people, including 12,000 cases of coronary heart disease, 9,000 cases of stroke, 18,000 cases of cardiovascular disease and cancer and 85,000 deaths, to assess the link between nuts and improved health. In research published in the journal BMC Medicine today experts from Imperial and the Norwegian University of Science and Technology found eating them was associated with a reduction in disease risk. Mr Aune said: “In nutritional studies so far much of the research has been on the big killers such as heart disease, stroke and cancer, but now we’re starting to see data for other diseases.

SOURCE…www.express.co.uk

 
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Hunter-gatherers’ Active lifestyles make the rest of us look shamefully lazy

As you tick off another sedentary day spent sitting in your office chair then lounging on your couch, it might strike you: human beings are surely “designed” to move more than this, right? We’re actually designed to move a whole lot more, suggests ongoing research into the lifestyles of hunter-gatherers. For a while now, anthropologists have been studying the Hadza — a tribe of less than 1000 from East Africa whose lives provide a window into how our ancestors lived hundreds of thousands of years ago

 We’ve already learned a lot from the Hadza about how might have slept and how our bodies evolved to efficiently burn the calories we eat, and new research suggests the “natural” amount of physical activity we need for good health.  A team of anthropologists — the University of Arizona’s David Raichlen, Yale University’s Brian Wood and Hunter College’s Herman Pontzer — strapped heart-rate monitors and GPS trackers to the Hadza, then analysed how far and fast they travelled each day.

Most days, the men walked briskly on the hunt for game animals, while the women foraged for and prepared wild foods.On average, the Hadza achieved about 75 minutes of moderate to vigorous physical activity a day.

To put that number in context, Australian health authorities recommend we engage in at least 150 minutes of moderate physical activity a week, or 75 minutes of vigorous physical activity a week.Most of us living modern Western lifestyles don’t meet those targets. In Australia, 60 percent of adults do less than 30 minutes of moderate physical activity per day — way below the Hadza.That matters because the Hadza have a super low risk of cardiovascular disease, including low rates of high blood pressure and blood cholesterol, unlike us in the West stricken by the so-called diseases of civilisation.

Another noteworthy finding about the Hadza’s physical activity: it doesn’t decline with age. The older Hadza (it’s not uncommon for them to live into their 70s and even 80s) stayed as active as younger generations — unlike our society, where physical activity drops off sharply as we age.Raichlen acknowledges the Hadza’s heart health is likely influenced by other factors too (such as their diets — most continue to forage and rely on wild foods), but says studying their lifestyles bolsters the obvious-but-overlooked theory that aerobic activity is a must for health.

“The overarching hypothesis is that our bodies evolved within a highly active context, and that explains why physical activity seems to improve physiological health today,” he said in a statement.He believes studying the Hadza gives us an insight into the physical activity levels that drove the evolution of healthy human hearts, muscles and brains.“The answer is not likely 30 minutes a day of walking on a treadmill,” he said. “It’s more like 75-plus minutes a day.”
Read more …./coach.nine.com.au

 

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Stroke Rates Rising in Younger People

Stroke rates have been declining in older people over the past 20 years — but have sharply increased in those under 55.

Researchers at Rutgers University used data from the New Jersey Department of Health on more than 227,000 hospitalizations for stroke from 1995 through 2014, calculating incidence by age over five-year periods. The findings appeared in the Journal of the American Heart Association.

Compared with the 1995-99 period, the rate of stroke in 2010-14 increased by 147 percent in people 35 to 39, by 101 percent in people 40 to 44, by 68 percent in those 45 to 49, and by 23 percent in the 50 to 54 group.Stroke is still far more common in older people. But the rate decreased by 11 percent in those 55 to 59, by 22 percent in the 60 to 64 group, and by 18 percent in people 65 to 69.The reasons are unclear, but the lead author, Joel N. Swerdel, now an epidemiologist with Janssen Pharmaceuticals, said that increasing obesity and diabetes in younger people are probably involved.

“For a person 30 to 50, the good news is you ain’t dead yet,” he said. “With behavioral changes, changing diet, increasing exercise, there’s still hope for you. Behavioral change is hard, but this study is an early warning sign.”

 

 

SOURCE…nytimes.com

 

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Understanding The Human Mind

 

Energy is this movement from possibility to actuality through a series of probabilities.

Dr. Dan Siegel is a clinical professor of psychiatry at the UCLA School of Medicine, the founding co-director of the Mindful Awareness Research Center at UCLA, and Executive Director of the Mindsight Institute. The author of multiple bestselling books on mindfulness, development, and neurobiology, Dr. Siegel joined Heleo’s Mandy Godwin on Facebook Live to discuss the mysteries of the human mind.

Mandy: Your new book, Mind, includes a quote by Albert Einstein, about how our idea of being separate from the rest of the world is an “optical delusion.” How is that?

Dan: Einstein used the word “delusion,” a psychotic belief that’s not consistent with reality. When you look at what the mind is, it might be something more than just brain activity. The interconnections we have make the self that comes from the mind not just a solo product, not just within your head. I think that’s what Einstein was referring to, that there’s something about the human condition that gets us to this false belief that we’re separate.

Mandy: Absolutely. In fact, something that you’ve brought up is that many of our disciplines aren’t even sure what we’re talking about when we refer to “mind.”

Dan: This is the reason I wrote the book, because the word “mind” does not have a definition in my original field, which is psychiatry. It doesn’t have a definition in the field of medicine. It doesn’t even have a definition in the field of psychology.

Mandy: What was the working definition of “mind” that you came up with?

Dan: The “mind” is some aspect of energy and information flow. Flow means change; information is a pattern of energy with symbolic value. Energy is this movement from possibility to actuality through a series of probabilities.

Mind, in the subjective experience of it, consciousness and information processing, can be some emergent property of energy and information flow.

Mandy: And where is our mind exactly?

Dan: Yes, people often say, “Well, my mind is. But where is it?” A lot of people turn to what Hippocrates said 2,500 years ago, which has been affirmed by scientists—it’s the common view: “mind is what brain does.” That puts the mind only in your head.

Of course the brain affects mental life, your feelings, your thoughts, your consciousness, memory, meaning, beliefs, attitudes, for sure, but is it limited to your skull? This is the issue.

Mandy: You mean, it’s not exclusively neural, it’s also social and interactive. So if it’s not just in your head, just in your skull, then where can you find the mind?

“The mind isn’t just influenced by other people—which is classic to social neuroscience— the mind emerges in the between-ness.”

Dan: You would find it throughout your whole body. Right now, your heart is influencing energy and information flow within your skin-encased body. It’s happening in your intestines. We know the bacteria that you ate this morning that you have in your intestines are going to affect the way you feel and think. Your intestines and your heart are a fundamental part of energy and information flow within your experience.

Right now, between me and you, we have energy and information flowing. Someone watching us could say, “Oh yeah, Mandy and Dan are talking. When Dan coughs, he keeps on putting his hand up [on the microphone],” because I have the mind of you and the mind of other people who are going to hear my coughing, so I cover this up so my coughing isn’t so loud. We have this interconnected mind.

If I were a person who were just thinking my mind came from my brain, I could say, “Well, our social signals influence each other.” What we’re saying here in this question, “Where is the mind?”, is the mind isn’t just influenced by other people—which is classic to social neuroscience—the mind emerges in the between-ness. There’s something happening right here, in the pattern of the way you’re responding to me. Studies show if we mirror each other, we’re going to secrete more oxytocin. We’re going to have a more compatible way of talking to each other than if I started doing stuff that showed I wasn’t resonating with you.

That’s a between-ness. We don’t become each other. We stay differentiated, but we become linked. That’s the “where,” as much between as within.

Mandy: Most of the time, what we hear about in studies is the mind as brain activity, neuroscience. We don’t hear much of that linkage outside. It seems novel in many ways.

Dan: I knew there would be people who would say, “Well, we know mind is just the brain activity, so why don’t you talk more about the brain?” I’ve written books like that, and there are lots of books written like that. Let’s look at the big picture of what the mind is. If you want a thing just on brain anatomy, go look at a book on brain anatomy. Let’s talk about the wholeness of the mind.

Mandy: You pose the question “when is the mind?” How does the concept of time apply to the mind?

Dan: You need to look into the science of time. Researching and writing this book helped illuminate something I had been feeling, but couldn’t really articulate, since I was about 11 years old. Sometimes in my mental life, I would have a feeling of, “Okay, time is passing, time is flowing, there’s not enough time, oh my God, things come and go.” At other times, I’d feel this timeless quality. Did you ever have that experience?

Mandy: Absolutely, especially when you’re really in the middle of something very engaging. There have been times where it seems as though a whole day can pass and you don’t even know, you’re immersed.

“It turns out that there isn’t something called time flowing, there’s just change happening. Time is really our awareness of change.”

Dan: Exactly, and other times you go, “Oh my God, I wish this would last forever.” Time is not something that flows like water in a river. Time as something that flows—we don’t have evidence for that. There is something called the arrow of time, which could be renamed the directionality of change. If you and I had an egg and cracked it open here, we couldn’t un-crack the egg. There’s a directionality of change. It’s now splayed all over the table. You can’t un-crack it.

It turns out that there isn’t something called time flowing, there’s just change happening. Time is really our awareness of change. There are macro-states that have this directionality of change, but there are micro-states that have no arrow of time, no directionality.

The answer to the “when” of mind is that macro-state energy and information flow patterns, like a thought, have a directionality—they come and they go. In this practice called “the wheel of awareness,” I think you can drop into a micro-state condition where consciousness arises and has no directionality of change. It is timeless. Some states of pure consciousness, which you can get at when you’re in the flow of things or when you do reflective practice, can enter this timeless state.

Mandy: You’ve talked about meditative practice, and how that might lead to more awareness.

Dan: Yes, you can open your awareness to all sorts of things. This is the issue of the immersion of the book. I wanted the book to be an experience, not just a download of information, to be relational as writing, to ask these questions rather than just give final answers, and to let the questioning connect the reader to their own inner experience, as well as to me, as we go on the journey together. Also to say, “Look, these questions can open up your own experience of your mind.”

The “why” of mind was, emotionally, the most challenging to write, because it’s a little audacious. It’s really a question: “Is there a why of mind?” For me, when I say the mind is a self-organizing emergent embodiment of the relational process, then the “why” of self-organization has an answer, and it’s integration.

Integration is where you take different parts and link them to create more well-being. Relationally, what it means is you create more kindness and compassion toward others, and even toward yourself. Another outcome is curiosity and creativity, and openness to life as it unfolds.

Mandy: That’s very hopeful. There’s a really interesting anecdote where you bring in this concept of feelings not having a scientific basis. That struck me—science doesn’t want to encounter feelings. One thing that your project has been taking on is that integration of the emotional life and the neural life.

Dan: I think the way to begin is to honor that science wants and needs to carefully observe things. Usually, it wants to measure things with numbers, to do statistical analyses, that’s fine. But what if the entity that we want to explore is something called subjective experience? Which would include emotions, but it also includes thoughts, perceptions, memories, beliefs, hopes, dreams, longings, attitudes, desires. That’s all the stuff of the mind. We put that under the phrase “subjective experience,” meaning you cannot really objectively measure it, or even observe it.

You and I see red, right? Even if we put 18 different options of red and we both pick the same one of the 18, I have no idea if the way you see red and the way I see red is the same. Poetry and art evoke subjective experiences. Even if I took a photograph, I have no idea if the feeling it evoked in me will be the feeling it evokes in you. You will have a subjective experience, and honoring that is important.

“You only get about 100 years in the body, but if you realize you are much more than your body, you’ve just achieved connection to people and living beings that were before you, and will be afterwards. You get this very different sense of vitality and meaning and purpose to life.”

From a scientific point of view, it’s important to recognize that you can’t observe subjective experience. The other thing is that, if we have teachings from our parents, from our schools, from society, that the self is a solo job that comes from your head, and that the mind is just brain activity, then what you say is, “Who you are is just your body.”

The sad outcome of that teaching is that you’re alone in this life. People feel so isolated because they see the “me” as separate. Then of course all you want to do is accumulate more stuff for “me,” get more for “me,” it’s about “me.” There’s not much in that that’s going to produce happiness or any positive outcome for the planet. What I talk about is an integrated identity, honoring that you have a “me” in the body, you get about 100 years to live in that body, awesome. Take care of the body well, exercise the body, feed the body, great. No one is saying the body isn’t important.

We’re also saying that differentiating the “me” within the body needs to be balanced with differentiating the “we” that is so under-recognized. That “we” identity needs to be talked about in homes and in classrooms and in the media. What’s been so exciting about it is people feel this opening up to a more authentic and real way of imagining where is your mind, who you are, why you’re here, what you can do with your life. You only get about 100 years in the body, but if you realize you are much more than your body, you’ve just achieved connection to people and living beings that were before you, and will be afterwards. You get this very different sense of vitality and meaning and purpose to life.

Unfortunately, in modern society, we’ve been living this very isolationist life. It’s a partial truth. To return to Einstein’s words, it’s an “optical delusion,” a psychotic belief. To be bold about it, it’s a lie that may be lethal. The more we believe that lie, the more we treat the planet like a trashcan, and there’s not much hope for the future.

Part of why I wrote the book was to open the conversation up with questions that can become a win-win-win situation. You get closer to the truth in yourself, that’s one win. You feel how you can develop well-being in your relationships with others, that’s the second win. The third win is that the planet is waiting for this transformation of our understanding of who we are and what to do with our lives collectively on Earth.

SOURCE…www.heleo.com